Could 3D Printing Advanced Ceramic Materials Assist Vaccine Development?

Various agencies around the world have long highlighted a potential pandemic as one of the greatest threats to humankind. Since before the outbreak of severe acute respiratory syndrome (SARS-COV) in 2002, institutions like the Centre for Disease Control (CDC) have developed various models for influenza pandemic planning. These models extol the importance of social distancing in buying time for immunologists to develop an effective vaccine. However, the conventional vaccine development timeline can be torturously slow.

Since the genetic sequence of the novel coronavirus, or COVID-19 (SARS-COV-2), was published in January 2020, there has been a concerted effort from academia and industry around the world to accelerate the vaccine development process. Advanced ceramic materials manufacturers have been among those looking to leverage next-generation technologies in the fight against COVID-19.

Among the many avenues currently under consideration is the use of 3D printing with advanced ceramic material feedstocks. An EU-funded project named NESSIE is geared specifically towards addressing the slow timeframes of vaccine development using additively-manufactured advanced ceramic material structures.

Understanding the Challenges of Vaccine Development

Vaccine development is a complex, often drawn-out process that typically combines the efforts of both public and private entities. Every step taken between initial exploratory stages (i.e. antigen identification) and market release is carefully controlled by regional authorities, with the degree of regulatory oversight typically intensifying throughout the development cycle. This can inhibit progression and drastically increase timescales, while also acting as a barrier to entry for innovative materials and new technologies into immunological spaces.

However, the global COVID-19 crisis has forced manufacturers and regulators alike to begin thinking outside the box when it comes to developing potential vaccines for the novel coronavirus.

Before we move on to discuss how 3D printing of advanced ceramic materials could help ease bottlenecks in vaccine development, it is worth highlighting that regulatory oversight is a medical necessity, and that slow time-to-market is a small price to pay for effective vaccines with negligible harmful side-effects.

How Can Advanced Ceramic Materials Help?

The NESSIE project uses ultra-high resolution advanced ceramic 3D printing technology to develop finely microporous absorbent columns for liquid chromatography (LC). In the context of vaccine development, LC is used to purify biopharmaceutical reagents – including antigenic material – that may be of limited quantities. These hybrid structures are a completely unique innovation, improving the quality of separations and significantly reducing production costs. Currently, the NESSIE project is looking to test these LC columns for adenovirus purification.

During the COVID-19 crisis, International Syalons has stayed open for business and intends to do so provided Government advice permits it. If you would like to discuss your research and development (R&D) needs or have concerns about advanced ceramic materials supply due to constricted supply chains, simply contact a member of the team today.




Posted in Uncategorized.